Friederike Zunke
Friederike Zunke
Molekulare Neurologie, Universitätsklinikum Erlangen/FAU
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Zitiert von
Zitiert von
α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
JR Mazzulli, F Zunke, O Isacson, L Studer, D Krainc
Proceedings of the National Academy of Sciences 113 (7), 1931-1936, 2016
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36
D Neculai, M Schwake, M Ravichandran, F Zunke, RF Collins, J Peters, ...
Nature 504 (7478), 172-176, 2013
Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson's patient midbrain neurons
JR Mazzulli, F Zunke, T Tsunemi, NJ Toker, S Jeon, LF Burbulla, ...
Journal of Neuroscience 36 (29), 7693-7706, 2016
The shedding protease ADAM17: physiology and pathophysiology
F Zunke, S Rose-John
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (11), 2059-2070, 2017
Reversible conformational conversion of α-synuclein into toxic assemblies by glucosylceramide
F Zunke, AC Moise, NR Belur, E Gelyana, I Stojkovska, H Dzaferbegovic, ...
Neuron 97 (1), 92-107. e10, 2018
Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor–mediated relaxation of renal arteries in hypertension
PS Chadha, F Zunke, HL Zhu, AJ Davis, TA Jepps, SP Olesen, WC Cole, ...
Hypertension 59 (4), 877-884, 2012
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
M Rothaug, F Zunke, JR Mazzulli, M Schweizer, H Altmeppen, ...
Proceedings of the National Academy of Sciences 111 (43), 15573-15578, 2014
Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries
PS Chadha, F Zunke, AJ Davis, TA Jepps, JTM Linders, M Schwake, ...
British journal of pharmacology 166 (4), 1377-1387, 2012
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease
M Rothaug, S Stroobants, M Schweizer, J Peters, F Zunke, M Allerding, ...
Acta neuropathologica communications 3 (1), 1-17, 2015
α-Synuclein in Parkinson’s disease: causal or bystander?
P Riederer, D Berg, N Casadei, F Cheng, J Classen, C Dresel, W Jost, ...
Journal of neural transmission 126 (7), 815-840, 2019
ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
S Schmidt, N Schumacher, J Schwarz, S Tangermann, L Kenner, ...
Journal of Experimental Medicine 215 (4), 1205-1225, 2018
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
F Zunke, L Andresen, S Wesseler, J Groth, P Arnold, M Rothaug, ...
Proceedings of the National Academy of Sciences 113 (14), 3791-3796, 2016
Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis
P Gaspar, WW Kallemeijn, A Strijland, S Scheij, M Van Eijk, J Aten, ...
Journal of lipid research 55 (1), 138-145, 2014
Mannose 6‐phosphate‐independent Lysosomal Sorting of LIMP‐2
J Blanz, F Zunke, S Markmann, M Damme, T Braulke, P Saftig, ...
Traffic 16 (10), 1127-1136, 2015
Stress-induced cellular clearance is mediated by the SNARE protein ykt6 and disrupted by α-Synuclein
LK Cuddy, WY Wani, ML Morella, C Pitcairn, K Tsutsumi, K Fredriksen, ...
Neuron 104 (5), 869-884. e11, 2019
Calcium negatively regulates meprin β activity and attenuates substrate cleavage
P Arnold, F Schmidt, J Prox, F Zunke, C Pietrzik, R Lucius, ...
The FASEB Journal 29 (8), 3549-3557, 2015
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease
J Peters, A Rittger, R Weisner, J Knabbe, F Zunke, M Rothaug, M Damme, ...
Biochemical and biophysical research communications 457 (3), 334-340, 2015
Alpha synuclein connects the gut-brain axis in Parkinson’s disease patients–a view on clinical aspects, cellular pathology and analytical methodology
E Schaeffer, A Kluge, M Böttner, F Zunke, F Cossais, D Berg, P Arnold
Frontiers in Cell and Developmental Biology 8, 910, 2020
Mutations in the B. 1.1. 7 SARS-CoV-2 spike protein reduce receptor-binding affinity and induce a flexible link to the fusion peptide
E Socher, M Conrad, L Heger, F Paulsen, H Sticht, F Zunke, P Arnold
Biomedicines 9 (5), 525, 2021
Structural and functional analyses of the shedding protease ADAM17 in HoxB8-immortalized macrophages and dendritic-like cells
AS Cabron, M Boss, P Arnold, J Schwarz, M Rosas, JP Dobert, ...
The Journal of Immunology 201 (10), 3106-3118, 2018
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