Hans Brandstetter
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The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
M Engel, T Hoffmann, L Wagner, M Wermann, U Heiser, R Kiefersauer, ...
Proceedings of the National Academy of Sciences 100 (9), 5063-5068, 2003
X-ray structure of active site-inhibited clotting factor Xa: implications for drug design and substrate recognition
H Brandstetter, A Kühne, W Bode, R Huber, W von der Saal, ...
Journal of Biological Chemistry 271 (47), 29988-29992, 1996
X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B
H Brandstetter, M Bauer, R Huber, P Lollar, W Bode
Proceedings of the National Academy of Sciences 92 (21), 9796-9800, 1995
Molecular machines for protein degradation
M Groll, M Bochtler, H Brandstetter, T Clausen, R Huber
Chembiochem 6 (2), 222-256, 2005
Refined 2· 3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA: A starting point …
H Brandstetter, D Turk, HW Hoeffken, D Grosse, J Stürzebecher, ...
Journal of molecular biology 226 (4), 1085-1099, 1992
Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): Implications for substrate gating and component interactions
AC Rosenzweig, H Brandstetter, DA Whittington, P Nordlund, SJ Lippard, ...
Proteins: Structure, Function, and Bioinformatics 29 (2), 141-152, 1997
Structural basis of the adaptive molecular recognition by MMP9
H Cha, E Kopetzki, R Huber, M Lanzendörfer, H Brandstetter
Journal of molecular biology 320 (5), 1065-1079, 2002
Structure and function of legumain in health and disease
E Dall, H Brandstetter
Biochimie 122, 126-150, 2016
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)
P Goettig, V Magdolen, H Brandstetter
Biochimie 92 (11), 1546-1567, 2010
The 1.8-Å crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition
H Brandstetter, F Grams, D Glitz, A Lang, R Huber, W Bode, HW Krell, ...
Journal of Biological Chemistry 276 (20), 17405-17412, 2001
Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C
W Bode, H Brandstetter, T Mather, MT Stubbs
Thrombosis and haemostasis 78 (07), 501-511, 1997
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation
E Dall, H Brandstetter
Proceedings of the National Academy of Sciences 110 (27), 10940-10945, 2013
Pyrimidine-2, 4, 6-triones: a new effective and selective class of matrix metalloproteinase inhibitors
F Grams, H Brandstetter, S DAlò, D Geppert, HW Krell, H Leinert, V Livi, ...
Walter de Gruyter 382 (8), 1277-1285, 2001
Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding
KP Hopfner, A Lang, A Karcher, K Sichler, E Kopetzki, H Brandstetter, ...
Structure 7 (8), 989-996, 1999
Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity
J Chang, J Jin, P Lollar, W Bode, H Brandstetter, N Hamaguchi, ...
Journal of Biological Chemistry 273 (20), 12089-12094, 1998
Enzyme flexibility, solvent and ‘weak’interactions characterize thrombin–ligand interactions: implications for drug design
RA Engh, H Brandstetter, G Sucher, A Eichinger, U Baumann, W Bode, ...
Structure 4 (11), 1353-1362, 1996
Investigations on the maturation and regulation of archaebacterial proteasomes
M Groll, H Brandstetter, H Bartunik, G Bourenkow, R Huber
Journal of molecular biology 327 (1), 75-83, 2003
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif
A Messerschmidt, S Macieira, M Velarde, M Bädeker, C Benda, A Jestel, ...
Journal of molecular biology 352 (4), 918-931, 2005
Crystal structure of the tricorn protease reveals a protein disassembly line
H Brandstetter, JS Kim, M Groll, R Huber
Nature 414 (6862), 466-470, 2001
Structure-Based Design and Synthesis of Potent Matrix Metalloproteinase Inhibitors Derived from a 6H-1,3,4-Thiadiazine Scaffold
J Schröder, A Henke, H Wenzel, H Brandstetter, HG Stammler, ...
Journal of medicinal chemistry 44 (20), 3231-3243, 2001
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