| The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism M Engel, T Hoffmann, L Wagner, M Wermann, U Heiser, R Kiefersauer, ... Proceedings of the National Academy of Sciences 100 (9), 5063-5068, 2003 | 430 | 2003 |
| X-ray structure of active site-inhibited clotting factor Xa: implications for drug design and substrate recognition H Brandstetter, A Kühne, W Bode, R Huber, W von der Saal, ... Journal of Biological Chemistry 271 (47), 29988-29992, 1996 | 353 | 1996 |
| X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. H Brandstetter, M Bauer, R Huber, P Lollar, W Bode Proceedings of the National Academy of Sciences 92 (21), 9796-9800, 1995 | 346 | 1995 |
| Molecular machines for protein degradation M Groll, M Bochtler, H Brandstetter, T Clausen, R Huber Chembiochem 6 (2), 222-256, 2005 | 284 | 2005 |
| Structure and function of legumain in health and disease E Dall, H Brandstetter Biochimie 122, 126-150, 2016 | 273 | 2016 |
| Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): Implications for substrate gating and component interactions AC Rosenzweig, H Brandstetter, DA Whittington, P Nordlund, SJ Lippard, ... Proteins: Structure, Function, and Bioinformatics 29 (2), 141-152, 1997 | 224 | 1997 |
| Refined 2· 3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA: A starting point … H Brandstetter, D Turk, HW Hoeffken, D Grosse, J Stürzebecher, ... Journal of molecular biology 226 (4), 1085-1099, 1992 | 216 | 1992 |
| Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation E Dall, H Brandstetter Proceedings of the National Academy of Sciences 110 (27), 10940-10945, 2013 | 207 | 2013 |
| Structural basis of the adaptive molecular recognition by MMP9 H Cha, E Kopetzki, R Huber, M Lanzendörfer, H Brandstetter Journal of molecular biology 320 (5), 1065-1079, 2002 | 179 | 2002 |
| Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs) P Goettig, V Magdolen, H Brandstetter Biochimie 92 (11), 1546-1567, 2010 | 174 | 2010 |
| Pyrimidine-2, 4, 6-Triones: a new effective and selective class of matrix metalloproteinase inhibitors F Grams, H Brandstetter, S DAlò, D Geppert, HW Krell, H Leinert, V Livi, ... Walter de Gruyter 382 (8), 1277-1285, 2001 | 157 | 2001 |
| The 1.8-Å crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition H Brandstetter, F Grams, D Glitz, A Lang, R Huber, W Bode, HW Krell, ... Journal of Biological Chemistry 276 (20), 17405-17412, 2001 | 156 | 2001 |
| Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity J Chang, J Jin, P Lollar, W Bode, H Brandstetter, N Hamaguchi, ... Journal of Biological Chemistry 273 (20), 12089-12094, 1998 | 155 | 1998 |
| Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding KP Hopfner, A Lang, A Karcher, K Sichler, E Kopetzki, H Brandstetter, ... Structure 7 (8), 989-996, 1999 | 144 | 1999 |
| Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C W Bode, H Brandstetter, T Mather, MT Stubbs Thrombosis and haemostasis 78 (07), 501-511, 1997 | 140 | 1997 |
| Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis U Eckhard, E Schönauer, D Nüss, H Brandstetter Nature structural & molecular biology 18 (10), 1109-1114, 2011 | 129 | 2011 |
| Investigations on the maturation and regulation of archaebacterial proteasomes M Groll, H Brandstetter, H Bartunik, G Bourenkow, R Huber Journal of molecular biology 327 (1), 75-83, 2003 | 124 | 2003 |
| Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif A Messerschmidt, S Macieira, M Velarde, M Bädeker, C Benda, A Jestel, ... Journal of molecular biology 352 (4), 918-931, 2005 | 123 | 2005 |
| Enzyme flexibility, solvent and ‘weak’interactions characterize thrombin–ligand interactions: implications for drug design RA Engh, H Brandstetter, G Sucher, A Eichinger, U Baumann, W Bode, ... Structure 4 (11), 1353-1362, 1996 | 123 | 1996 |
| Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease Z Zhang, O Obianyo, E Dall, Y Du, H Fu, X Liu, SS Kang, M Song, SP Yu, ... Nature communications 8 (1), 14740, 2017 | 120 | 2017 |
Peter BrizaUniversity of SalzburgVerified email at sbg.ac.at
