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Johan Ledin
Johan Ledin
Researcher in Developmental Biology, Uppsala University
Bestätigte E-Mail-Adresse bei ebc.uu.se
Titel
Zitiert von
Zitiert von
Jahr
Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
E Forsberg, G Pejler, M Ringvall, C Lunderius, B Tomasini-Johansson, ...
Nature 400 (6746), 773-776, 1999
5721999
High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9
GK Varshney, W Pei, MC LaFave, J Idol, L Xu, V Gallardo, B Carrington, ...
Genome research 25 (7), 1030-1042, 2015
5432015
Heparan sulfate structure in mice with genetically modified heparan sulfate production
J Ledin, W Staatz, JP Li, M Götte, S Selleck, L Kjellén, D Spillmann
Journal of Biological Chemistry 279 (41), 42732-42741, 2004
3142004
Defective heparan sulfate biosynthesis and neonatal lethality in mice lackingN-deacetylase/N-sulfotransferase-1
M Ringvall, J Ledin, K Holmborn, T van Kuppevelt, F Ellin, I Eriksson, ...
Journal of Biological Chemistry 275 (34), 25926-25930, 2000
3052000
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
A Abramsson, S Kurup, M Busse, S Yamada, P Lindblom, E Schallmeiner, ...
Genes & development 21 (3), 316-331, 2007
2172007
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
K Grobe, J Ledin, M Ringvall, K Holmborn, E Forsberg, JD Esko, L Kjellén
Biochimica et Biophysica Acta (BBA)-General Subjects 1573 (3), 209-215, 2002
1992002
A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish
GK Varshney, B Carrington, W Pei, K Bishop, Z Chen, C Fan, L Xu, ...
Nature protocols 11 (12), 2357-2375, 2016
1932016
HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development
WHJ Norton, J Ledin, H Grandel, CJ Neumann
Oxford University Press for The Company of Biologists Limited 132 (22), 4963 …, 2005
1672005
Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups
K Holmborn, J Ledin, E Smeds, I Eriksson, M Kusche-Gullberg, L Kjellén
Journal of Biological Chemistry 279 (41), 42355-42358, 2004
1332004
Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis
AJ Hayes, S Reynolds, MA Nowell, LB Meakin, J Habicher, J Ledin, ...
PloS one 8 (9), e75787, 2013
782013
Altered storage of proteases in mast cells from mice lacking heparin: A possible role for heparin carboxypeptidase A processing
F Henningsson, J Ledin, C Lunderius, M Wilén, L Hellman, G Pejler
Walter de Gruyter 383 (5), 793-801, 2002
692002
On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis
K Holmborn, J Habicher, Z Kasza, AS Eriksson, B Filipek-Gorniok, ...
Journal of Biological Chemistry 287 (40), 33905-33916, 2012
632012
Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation
J Ledin, M Ringvall, M Thuveson, I Eriksson, M Wilén, M Kusche-Gullberg, ...
Journal of biological chemistry 281 (47), 35727-35734, 2006
582006
CRISPRz: a database of zebrafish validated sgRNAs
GK Varshney, S Zhang, W Pei, A Adomako-Ankomah, J Fohtung, ...
Nucleic acids research 44 (D1), D822-D826, 2016
452016
Zebrafish embryo as a replacement model for initial biocompatibility studies of biomaterials and drug delivery systems
TSP Rothenbücher, J Ledin, D Gibbs, H Engqvist, C Persson, ...
Acta biomaterialia 100, 235-243, 2019
352019
TAF1, associated with intellectual disability in humans, is essential for embryogenesis and regulates neurodevelopmental processes in zebrafish
S Gudmundsson, M Wilbe, B Filipek-Górniok, AM Molin, S Ekvall, ...
Scientific Reports 9 (1), 10730, 2019
332019
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension
M Morikawa, Y Mitani, K Holmborn, T Kato, D Koinuma, J Maruyama, ...
Science signaling 12 (607), eaay4430, 2019
302019
Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development
B Filipek‐Górniok, K Holmborn, T Haitina, J Habicher, MB Oliveira, ...
Developmental dynamics 242 (8), 964-975, 2013
242013
Chondroitin/dermatan sulfate modification enzymes in zebrafish development
J Habicher, T Haitina, I Eriksson, K Holmborn, T Dierker, PE Ahlberg, ...
PLoS One 10 (3), e0121957, 2015
232015
The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation
B Filipek-Gorniok, P Carlsson, T Haitina, J Habicher, J Ledin, L Kjellen
PLoS One 10 (3), e0119040, 2015
222015
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