| A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels M Schewe, H Sun, Ü Mert, A Mackenzie, ACW Pike, F Schulz, ... Science 363 (6429), 875-880, 2019 | 115 | 2019 |
| Gain‐of‐function mutation in TASK‐4 channels and severe cardiac conduction disorder C Friedrich, S Rinné, S Zumhagen, AK Kiper, N Silbernagel, MF Netter, ... EMBO molecular medicine 6 (7), 937-951, 2014 | 78 | 2014 |
| Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia N Decher, B Ortiz‐Bonnin, C Friedrich, M Schewe, AK Kiper, S Rinné, ... EMBO molecular medicine 9 (4), 403-414, 2017 | 69 | 2017 |
| A lower X-gate in TASK channels traps inhibitors within the vestibule KEJ Rödström, AK Kiper, W Zhang, S Rinne, ACW Pike, M Goldstein, ... Nature 582 (7812), 443-447, 2020 | 68 | 2020 |
| Kv1. 5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? AK Kiper, S Rinné, C Rolfes, D Ramírez, G Seebohm, MF Netter, ... Pflügers Archiv-European Journal of Physiology 467, 1081-1090, 2015 | 68 | 2015 |
| TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes S Rinné, AK Kiper, G Schlichthörl, S Dittmann, MF Netter, SH Limberg, ... Journal of Molecular and Cellular Cardiology 81, 71-80, 2015 | 51 | 2015 |
| Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias N Decher, AK Kiper, S Rinné Progress in biophysics and molecular biology 130, 223-232, 2017 | 41 | 2017 |
| The role of acid-sensitive two-pore domain potassium channels in cardiac electrophysiology: focus on arrhythmias N Decher, AK Kiper, C Rolfes, E Schulze-Bahr, S Rinné Pflügers Archiv-European Journal of Physiology 467, 1055-1067, 2015 | 28 | 2015 |
| The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels S Rinne, AK Kiper, KS Vowinkel, D Ramírez, M Schewe, M Bedoya, ... Elife 8, e39476, 2019 | 24 | 2019 |
| Identification of the A293 (AVE1231) binding site in the cardiac two-pore-domain potassium channel task-1: a common low affinity antiarrhythmic drug binding site F Wiedmann, AK Kiper, M Bedoya, A Ratte, S Rinné, M Kraft, M Waibel, ... Cell Physiol Biochem 52, 1223-1235, 2019 | 24 | 2019 |
| The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function N Silbernagel, M Walecki, MKH Schäfer, M Kessler, M Zobeiri, S Rinné, ... The FASEB Journal 32 (11), 6159, 2018 | 24 | 2018 |
| Functional mutagenesis screens reveal the ‘cap structure’formation in disulfide-bridge free TASK channels M Goldstein, S Rinné, AK Kiper, D Ramírez, MF Netter, D Bustos, ... Scientific Reports 6 (1), 19492, 2016 | 22 | 2016 |
| Discovery of novel TASK-3 channel blockers using a pharmacophore-based virtual screening D Ramírez, G Concha, B Arévalo, L Prent-Peñaloza, L Zúñiga, AK Kiper, ... International Journal of Molecular Sciences 20 (16), 4014, 2019 | 21 | 2019 |
| POPDC2 a novel susceptibility gene for conduction disorders S Rinné, B Ortiz-Bonnin, B Stallmeyer, AK Kiper, L Fortmüller, ... Journal of Molecular and Cellular Cardiology 145, 74-83, 2020 | 20 | 2020 |
| TASK channels pharmacology: new challenges in drug design M Bedoya, S Rinné, AK Kiper, N Decher, W González, D Ramírez Journal of Medicinal Chemistry 62 (22), 10044-10058, 2019 | 19 | 2019 |
| Molecular Pharmacology of K N Dechera, S Rinnéa, M Bedoyab, W Gonzalezb, AK Kipera Cell Physiol Biochem 55 (S3), 87-107, 2021 | 16 | 2021 |
| Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5, 6, 7, 8 tetrahydropyrido [4, 3-d] pyrimidine D Ramírez, M Bedoya, AK Kiper, S Rinné, S Morales-Navarro, ... International Journal of Molecular Sciences 20 (9), 2252, 2019 | 16 | 2019 |
| Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease LA Matschke, MA Komadowski, A Stöhr, B Lee, MT Henrich, M Griesbach, ... Scientific Reports 12 (1), 3180, 2022 | 13 | 2022 |
| An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities K Wemhöner, T Kanyshkova, N Silbernagel, J Fernandez-Orth, S Bittner, ... Frontiers in molecular neuroscience 8, 63, 2015 | 11 | 2015 |
| 5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis D Ramírez, M Mejia-Gutierrez, B Insuasty, S Rinné, AK Kiper, M Platzk, ... Molecules 26 (13), 3897, 2021 | 8 | 2021 |
