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Brian C. Capell, MD, PhD
Brian C. Capell, MD, PhD
Assistant Professor of Dermatology and Genetics, University of Pennsylvania
Bestätigte E-Mail-Adresse bei uphs.upenn.edu
Titel
Zitiert von
Zitiert von
Jahr
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Z Dou, K Ghosh, MG Vizioli, J Zhu, P Sen, KJ Wangensteen, J Simithy, ...
Nature 550 (7676), 402-406, 2017
10142017
Human laminopathies: nuclei gone genetically awry
BC Capell, FS Collins
Nature reviews genetics 7 (12), 940-952, 2006
6162006
Autophagy mediates degradation of nuclear lamina
Z Dou, C Xu, G Donahue, T Shimi, JA Pan, J Zhu, A Ivanov, BC Capell, ...
Nature 527 (7576), 105-109, 2015
6052015
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
PP Shah, G Donahue, GL Otte, BC Capell, DM Nelson, K Cao, ...
Genes & development 27 (16), 1787-1799, 2013
5282013
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
BC Capell, MR Erdos, JP Madigan, JJ Fiordalisi, R Varga, KN Conneely, ...
Proceedings of the National Academy of Sciences 102 (36), 12879-12884, 2005
4532005
A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells
K Cao, BC Capell, MR Erdos, K Djabali, FS Collins
Proceedings of the National Academy of Sciences 104 (12), 4949-4954, 2007
3112007
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson–Gilford progeria syndrome
R Varga, M Eriksson, MR Erdos, M Olive, I Harten, F Kolodgie, BC Capell, ...
Proceedings of the National Academy of Sciences 103 (9), 3250-3255, 2006
2932006
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
BC Capell, M Olive, MR Erdos, K Cao, DA Faddah, UL Tavarez, ...
Proceedings of the National Academy of Sciences 105 (41), 15902-15907, 2008
2302008
Mechanisms of cardiovascular disease in accelerated aging syndromes
BC Capell, FS Collins, EG Nabel
Circulation Research 101 (1), 13-26, 2007
1522007
Magnetic resonance imaging in quantitative analysis of rotator cuff muscle volume.
MJ Tingart, M Apreleva, JT Lehtinen, B Capell, WE Palmer, JJP Warner
Clinical Orthopaedics and Related Research (1976-2007) 415, 104-110, 2003
1472003
MLL1 is essential for the senescence-associated secretory phenotype
BC Capell, AM Drake, J Zhu, PP Shah, Z Dou, J Dorsey, DF Simola, ...
Genes & development 30 (3), 321-336, 2016
1442016
The senescence-associated secretory phenotype: critical effector in skin cancer and aging
K Ghosh, BC Capell
Journal of Investigative Dermatology 136 (11), 2133-2139, 2016
1402016
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
AS McNeal, K Liu, V Nakhate, CA Natale, EK Duperret, BC Capell, ...
Cancer discovery 5 (10), 1072-1085, 2015
1062015
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
E Lin-Shiao, Y Lan, M Coradin, A Anderson, G Donahue, CL Simpson, ...
Genes & development 32 (2), 181-193, 2018
862018
Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
VLRM Verstraeten, LA Peckham, M Olive, BC Capell, FS Collins, ...
Proceedings of the National Academy of Sciences 108 (12), 4997-5002, 2011
842011
From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging
BC Capell, BE Tlougan, SJ Orlow
Journal of Investigative Dermatology 129 (10), 2340-2350, 2009
632009
LSD1 inhibition promotes epithelial differentiation through derepression of fate-determining transcription factors
S Egolf, Y Aubert, M Doepner, A Anderson, A Maldonado-Lopez, ...
Cell reports 28 (8), 1981-1992. e7, 2019
592019
Human longevity and common variations in the LMNA gene: a meta‐analysis
KN Conneely, BC Capell, MR Erdos, P Sebastiani, N Solovieff, AJ Swift, ...
Aging cell 11 (3), 475-481, 2012
532012
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization
S Huang, P Kuri, Y Aubert, M Brewster, N Li, O Farrelly, G Rice, H Bae, ...
Cell Stem Cell 28 (9), 1582-1596. e6, 2021
522021
Pharmacologic activation of the G protein–coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma
CA Natale, J Li, JR Pitarresi, RJ Norgard, T Dentchev, BC Capell, ...
Cellular and Molecular Gastroenterology and Hepatology 10 (4), 868-880. e1, 2020
452020
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