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Lukas Simon
Lukas Simon
Verified email at bcm.edu
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Year
PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells
FA Wolf, FK Hamey, M Plass, J Solana, JS Dahlin, B Göttgens, ...
Genome biology 20, 1-9, 2019
11262019
Single-cell RNA-seq denoising using a deep count autoencoder
G Eraslan, LM Simon, M Mircea, NS Mueller, FJ Theis
Nature communications 10 (1), 390, 2019
8592019
A cellular census of human lungs identifies novel cell states in health and in asthma
FA Vieira Braga, G Kar, M Berg, OA Carpaij, K Polanski, LM Simon, ...
Nature medicine 25 (7), 1153-1163, 2019
7462019
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
I Angelidis, LM Simon, IE Fernandez, M Strunz, CH Mayr, FR Greiffo, ...
Nature communications 10 (1), 963, 2019
5012019
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
TYT Hsu, LM Simon, NJ Neill, R Marcotte, A Sayad, CS Bland, ...
Nature 525 (7569), 384-388, 2015
4642015
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
M Strunz, LM Simon, M Ansari, JJ Kathiriya, I Angelidis, CH Mayr, ...
Nature communications 11 (1), 3559, 2020
4282020
Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
LM Simon, LC Edelstein, S Nagalla, AB Woodley, ES Chen, X Kong, L Ma, ...
Blood, The Journal of the American Society of Hematology 123 (16), e37-e45, 2014
2492014
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
LC Edelstein, LM Simon, RT Montoya, M Holinstat, ES Chen, A Bergeron, ...
Nature medicine 19 (12), 1609-1616, 2013
2322013
The human lung cell atlas: a high-resolution reference map of the human lung in health and disease
HB Schiller, DT Montoro, LM Simon, EL Rawlins, KB Meyer, M Strunz, ...
American journal of respiratory cell and molecular biology 61 (1), 31-41, 2019
2172019
Single cells make big data: new challenges and opportunities in transcriptomics
P Angerer, L Simon, S Tritschler, FA Wolf, D Fischer, FJ Theis
Current opinion in systems biology 4, 85-91, 2017
2132017
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
X Sheng, HZ Nenseth, S Qu, OF Kuzu, T Frahnow, L Simon, S Greene, ...
Nature communications 10 (1), 323, 2019
1902019
EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
D Neelakantan, H Zhou, MUJ Oliphant, X Zhang, LM Simon, DM Henke, ...
Nature communications 8 (1), 15773, 2017
1562017
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
C Krendl, D Shaposhnikov, V Rishko, C Ori, C Ziegenhain, S Sass, ...
Proceedings of the National Academy of Sciences 114 (45), E9579-E9588, 2017
1322017
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
LC Edelstein, LM Simon, CR Lindsay, X Kong, R Teruel-Montoya, ...
Blood, The Journal of the American Society of Hematology 124 (23), 3450-3458, 2014
1232014
A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection
K Saxena, LM Simon, XL Zeng, SE Blutt, SE Crawford, NP Sastri, ...
Proceedings of the National Academy of Sciences 114 (4), E570-E579, 2017
1212017
Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
EA Bowling, JH Wang, F Gong, W Wu, NJ Neill, IS Kim, S Tyagi, ...
Cell 184 (2), 384-403. e21, 2021
1172021
Charting extracellular transcriptomes in the human biofluid RNA atlas
E Hulstaert, A Morlion, FA Cobos, K Verniers, J Nuytens, EV Eynde, ...
Cell reports 33 (13), 2020
682020
CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT
A Chaudhury, S Cheema, JM Fachini, N Kongchan, G Lu, LM Simon, ...
Nature communications 7 (1), 13362, 2016
662016
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers
CH Mayr, LM Simon, G Leuschner, M Ansari, J Schniering, PE Geyer, ...
EMBO molecular medicine 13 (4), e12871, 2021
652021
Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer
V Sethunath, H Hu, C De Angelis, J Veeraraghavan, L Qin, N Wang, ...
Molecular Cancer Research 17 (11), 2318-2330, 2019
532019
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