PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells FA Wolf, FK Hamey, M Plass, J Solana, JS Dahlin, B Göttgens, ... Genome biology 20, 1-9, 2019 | 1220 | 2019 |
Single-cell RNA-seq denoising using a deep count autoencoder G Eraslan, LM Simon, M Mircea, NS Mueller, FJ Theis Nature communications 10 (1), 390, 2019 | 908 | 2019 |
A cellular census of human lungs identifies novel cell states in health and in asthma FA Vieira Braga, G Kar, M Berg, OA Carpaij, K Polanski, LM Simon, ... Nature medicine 25 (7), 1153-1163, 2019 | 783 | 2019 |
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics I Angelidis, LM Simon, IE Fernandez, M Strunz, CH Mayr, FR Greiffo, ... Nature communications 10 (1), 963, 2019 | 539 | 2019 |
The spliceosome is a therapeutic vulnerability in MYC-driven cancer TYT Hsu, LM Simon, NJ Neill, R Marcotte, A Sayad, CS Bland, ... Nature 525 (7569), 384-388, 2015 | 486 | 2015 |
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis M Strunz, LM Simon, M Ansari, JJ Kathiriya, I Angelidis, CH Mayr, ... Nature communications 11 (1), 3559, 2020 | 474 | 2020 |
Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics LM Simon, LC Edelstein, S Nagalla, AB Woodley, ES Chen, X Kong, L Ma, ... Blood, The Journal of the American Society of Hematology 123 (16), e37-e45, 2014 | 258 | 2014 |
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c LC Edelstein, LM Simon, RT Montoya, M Holinstat, ES Chen, A Bergeron, ... Nature medicine 19 (12), 1609-1616, 2013 | 238 | 2013 |
The human lung cell atlas: a high-resolution reference map of the human lung in health and disease HB Schiller, DT Montoro, LM Simon, EL Rawlins, KB Meyer, M Strunz, ... American journal of respiratory cell and molecular biology 61 (1), 31-41, 2019 | 232 | 2019 |
Single cells make big data: new challenges and opportunities in transcriptomics P Angerer, L Simon, S Tritschler, FA Wolf, D Fischer, FJ Theis Current opinion in systems biology 4, 85-91, 2017 | 217 | 2017 |
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling X Sheng, HZ Nenseth, S Qu, OF Kuzu, T Frahnow, L Simon, S Greene, ... Nature communications 10 (1), 323, 2019 | 198 | 2019 |
EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells D Neelakantan, H Zhou, MUJ Oliphant, X Zhang, LM Simon, DM Henke, ... Nature communications 8 (1), 15773, 2017 | 165 | 2017 |
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency C Krendl, D Shaposhnikov, V Rishko, C Ori, C Ziegenhain, S Sass, ... Proceedings of the National Academy of Sciences 114 (45), E9579-E9588, 2017 | 138 | 2017 |
Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer EA Bowling, JH Wang, F Gong, W Wu, NJ Neill, IS Kim, S Tyagi, ... Cell 184 (2), 384-403. e21, 2021 | 132 | 2021 |
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race LC Edelstein, LM Simon, CR Lindsay, X Kong, R Teruel-Montoya, ... Blood, The Journal of the American Society of Hematology 124 (23), 3450-3458, 2014 | 127 | 2014 |
A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection K Saxena, LM Simon, XL Zeng, SE Blutt, SE Crawford, NP Sastri, ... Proceedings of the National Academy of Sciences 114 (4), E570-E579, 2017 | 124 | 2017 |
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers CH Mayr, LM Simon, G Leuschner, M Ansari, J Schniering, PE Geyer, ... EMBO molecular medicine 13 (4), e12871, 2021 | 76 | 2021 |
Charting extracellular transcriptomes in the human biofluid RNA atlas E Hulstaert, A Morlion, FA Cobos, K Verniers, J Nuytens, EV Eynde, ... Cell Reports 33 (13), 2020 | 75 | 2020 |
CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT A Chaudhury, S Cheema, JM Fachini, N Kongchan, G Lu, LM Simon, ... Nature communications 7 (1), 13362, 2016 | 69 | 2016 |
Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer V Sethunath, H Hu, C De Angelis, J Veeraraghavan, L Qin, N Wang, ... Molecular Cancer Research 17 (11), 2318-2330, 2019 | 56 | 2019 |