Lukas Simon
Lukas Simon
Verified email at helmholtz-muenchen.de
TitleCited byYear
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
TYT Hsu, LM Simon, NJ Neill, R Marcotte, A Sayad, CS Bland, ...
Nature 525 (7569), 384, 2015
1502015
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
LC Edelstein, LM Simon, RT Montoya, M Holinstat, ES Chen, A Bergeron, ...
Nature medicine 19 (12), 1609, 2013
1132013
Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
LM Simon, LC Edelstein, S Nagalla, AB Woodley, ES Chen, X Kong, L Ma, ...
Blood, blood-2013-12-544692, 2014
982014
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
LC Edelstein, LM Simon, CR Lindsay, X Kong, RT Montoya, BE Tourdot, ...
Blood, blood-2014-04-572479, 2014
552014
A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection
K Saxena, LM Simon, XL Zeng, SE Blutt, SE Crawford, NP Sastri, ...
Proceedings of the National Academy of Sciences 114 (4), E570-E579, 2017
272017
EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
D Neelakantan, H Zhou, MUJ Oliphant, X Zhang, LM Simon, DM Henke, ...
Nature communications 8, 15773, 2017
202017
CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT
A Chaudhury, S Cheema, JM Fachini, N Kongchan, G Lu, LM Simon, ...
Nature communications 7, 13362, 2016
172016
Single cells make big data: new challenges and opportunities in transcriptomics
P Angerer, L Simon, S Tritschler, FA Wolf, D Fischer, FJ Theis
Current Opinion in Systems Biology 4, 85-91, 2017
132017
Integrative multi-omic analysis of human platelet eQTLs reveals alternative start site in mitofusin 2
LM Simon, ES Chen, LC Edelstein, X Kong, S Bhatlekar, I Rigoutsos, ...
The American Journal of Human Genetics 98 (5), 883-897, 2016
92016
Graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells
FA Wolf, F Hamey, M Plass, J Solana, JS Dahlin, B Gottgens, N Rajewsky, ...
bioRxiv, 2017
52017
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
C Krendl, D Shaposhnikov, V Rishko, C Ori, C Ziegenhain, S Sass, ...
Proceedings of the National Academy of Sciences 114 (45), E9579-E9588, 2017
42017
Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP
X Kong, LM Simon, M Holinstat, CA Shaw, PF Bray, LC Edelstein
Thrombosis and haemostasis 117 (5), 962, 2017
22017
Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial
P Tricoci, M Neely, MJ Whitley, LC Edelstein, LM Simon, C Shaw, ...
Blood Cells, Molecules, and Diseases 72, 37-43, 2018
12018
Single cell RNA-seq denoising using a deep count autoencoder
G Eraslan, LM Simon, M Mircea, NS Mueller, FJ Theis
bioRxiv, 300681, 2018
12018
SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume
S Zou, AM Teixeira, M Kostadima, WJ Astle, A Radhakrishnan, LM Simon, ...
PloS one 12 (5), e0178095, 2017
12017
Abstract B04: Identification of molecular predictors of differential chemotherapy response using patient-derived xenografts
MT Lewis, LE Dobrolecki, SG Hilsenbeck, LM Simon, CA Shaw
Clinical Cancer Research 22 (16 Supplement), B04-B04, 2016
12016
Identification of molecular predictors of differential chemotherapy response using patient-derived xenografts
MT Lewis, LE Dobrolecki, SG Hilsenbeck, LM Simon, CA Shaw
Cancer Research 76 (14 Supplement), 5193-5193, 2016
12016
Mevalonate pathway mediates acquired anti-HER2 treatment resistance in HER2+ breast cancer
H Hu, L Simon, L Qin, A Nardone, C Shaw, G Chamness, L Heiser, ...
Cancer Research 75 (15 Supplement), 721-721, 2015
12015
A large cluster of micrornas At 14q32 defines an RNA expression module that accounts for racial differences in protease activated receptor 4-mediated platelet reactivity
LC Edelstein, LM Simon, E Chen, A Bergeron, X Kong, L Ma, ...
Blood 120 (21), 380-380, 2012
12012
The protease‐activated receptor 4 Ala120Thr variant alters platelet responsiveness to low‐dose thrombin and protease‐activated receptor 4 desensitization, and is blocked by non …
MJ Whitley, DM Henke, A Ghazi, M Nieman, M Stoller, LM Simon, E Chen, ...
Journal of Thrombosis and Haemostasis 16 (12), 2501-2514, 2018
2018
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Articles 1–20