| Hypoxia and hypoxia-inducible factor-1α modulate lipopolysaccharide-induced dendritic cell activation and function J Jantsch, D Chakravortty, N Turza, AT Prechtel, B Buchholz, RG Gerlach, ... The Journal of Immunology 180 (7), 4697-4705, 2008 | 473 | 2008 |
| TRPP2 and TRPV4 form a polymodal sensory channel complex M Köttgen, B Buchholz, MA Garcia-Gonzalez, F Kotsis, X Fu, M Doerken, ... The Journal of cell biology 182 (3), 437-447, 2008 | 422 | 2008 |
| Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation M Köttgen, T Benzing, T Simmen, R Tauber, B Buchholz, S Feliciangeli, ... The EMBO journal 24 (4), 705-716, 2005 | 286 | 2005 |
| HIF activation protects from acute kidney injury A Weidemann, WM Bernhardt, B Klanke, C Daniel, B Buchholz, V Ca, ... Journal of the American Society of Nephrology 19 (3), 486-494, 2008 | 209 | 2008 |
| Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model WM Bernhardt, U Gottmann, F Doyon, B Buchholz, V Campean, J Schödel, ... Proceedings of the National Academy of Sciences 106 (50), 21276-21281, 2009 | 165 | 2009 |
| TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum T Wegierski, D Steffl, C Kopp, R Tauber, B Buchholz, R Nitschke, ... The EMBO journal 28 (5), 490-499, 2009 | 125 | 2009 |
| HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury J Schödel, B Klanke, A Weidemann, B Buchholz, W Bernhardt, M Bertog, ... The American journal of pathology 174 (5), 1663-1674, 2009 | 103 | 2009 |
| Lipid peroxidation drives renal cyst growth in vitro through activation of TMEM16A R Schreiber, B Buchholz, A Kraus, G Schley, J Scholz, J Ousingsawat, ... Journal of the American Society of Nephrology 30 (2), 228-242, 2019 | 79 | 2019 |
| HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease A Kraus, DJM Peters, B Klanke, A Weidemann, C Willam, G Schley, ... Kidney international 94 (5), 887-899, 2018 | 77 | 2018 |
| Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells B Buchholz, D Faria, G Schley, R Schreiber, KU Eckardt, K Kunzelmann Kidney international 85 (5), 1058-1067, 2014 | 75 | 2014 |
| Hypoxia-inducible factor-1α causes renal cyst expansion through calcium-activated chloride secretion B Buchholz, G Schley, D Faria, S Kroening, C Willam, R Schreiber, ... Journal of the American Society of Nephrology 25 (3), 465-474, 2014 | 72 | 2014 |
| Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo I Cabrita, A Kraus, JK Scholz, K Skoczynski, R Schreiber, K Kunzelmann, ... Nature communications 11 (1), 4320, 2020 | 62 | 2020 |
| Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP-and ATP-mediated fluid secretion B Buchholz, B Teschemacher, G Schley, H Schillers, KU Eckardt Journal of molecular medicine 89, 251-261, 2011 | 58 | 2011 |
| Increased expression of secreted frizzled-related protein 4 in polycystic kidneys D Romaker, M Puetz, S Teschner, J Donauer, M Geyer, P Gerke, ... Journal of the American Society of Nephrology 20 (1), 48-56, 2009 | 49 | 2009 |
| Risk factors for early dialysis dependency in autosomal recessive polycystic kidney disease K Burgmaier, K Kunzmann, G Ariceta, C Bergmann, AK Buescher, ... The Journal of pediatrics 199, 22-28. e6, 2018 | 48 | 2018 |
| The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis B Buchholz, B Klanke, G Schley, G Bollag, J Tsai, S Kroening, ... Nephrology Dialysis Transplantation 26 (11), 3458-3465, 2011 | 48 | 2011 |
| Refining genotype–phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants K Burgmaier, L Brinker, F Erger, BB Beck, MR Benz, C Bergmann, ... Kidney international 100 (3), 650-659, 2021 | 40 | 2021 |
| Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells C Boehlke, F Kotsis, B Buchholz, C Powelske, KU Eckardt, G Walz, ... PloS one 8 (5), e62165, 2013 | 39 | 2013 |
| Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease IN Schellinger, N Cordasic, J Panesar, B Buchholz, J Jacobi, A Hartner, ... Kidney international 91 (3), 616-627, 2017 | 35 | 2017 |
| P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells A Kraus, S Grampp, M Goppelt-Struebe, R Schreiber, K Kunzelmann, ... Purinergic signalling 12, 687-695, 2016 | 34 | 2016 |
Michael KöttgenUniversity of Freiburg, Department of Medicine IVVerified email at uniklinik-freiburg.de
