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Avid M. Afzal
Avid M. Afzal
Verified email at astrazeneca.com
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Cited by
Year
Target prediction utilising negative bioactivity data covering large chemical space
LH Mervin, AM Afzal, G Drakakis, R Lewis, O Engkvist, A Bender
Journal of cheminformatics 7, 1-16, 2015
1292015
FAst MEtabolizer (FAME): A rapid and accurate predictor of sites of metabolism in multiple species by endogenous enzymes
J Kirchmair, MJ Williamson, AM Afzal, JD Tyzack, APK Choy, A Howlett, ...
Journal of chemical information and modeling 53 (11), 2896-2907, 2013
622013
Orthologue chemical space and its influence on target prediction
LH Mervin, KC Bulusu, L Kalash, AM Afzal, F Svensson, MA Firth, I Barrett, ...
Bioinformatics 34 (1), 72-79, 2018
402018
A multi-label approach to target prediction taking ligand promiscuity into account
AM Afzal, HY Mussa, RE Turner, A Bender, RC Glen
Journal of cheminformatics 7, 1-14, 2015
382015
A Bayesian neural network for toxicity prediction
E Semenova, DP Williams, AM Afzal, SE Lazic
Computational Toxicology 16, 100133, 2020
352020
Comparison of chemical structure and cell morphology information for multitask bioactivity predictions
MA Trapotsi, LH Mervin, AM Afzal, N Sturm, O Engkvist, IP Barrett, ...
Journal of chemical information and modeling 61 (3), 1444-1456, 2021
292021
Bioinformatics: Concepts, methods, and data
SW Robinson, AM Afzal, DP Leader
Handbook of Pharmacogenomics and stratified medicine, 259-287, 2014
242014
Maximizing gain in high-throughput screening using conformal prediction
F Svensson, AM Afzal, U Norinder, A Bender
Journal of cheminformatics 10, 1-10, 2018
222018
Comparison of scaling methods to obtain calibrated probabilities of activity for protein–ligand predictions
LH Mervin, AM Afzal, O Engkvist, A Bender
Journal of Chemical Information and Modeling 60 (10), 4546-4559, 2020
182020
The Parzen Window method: In terms of two vectors and one matrix
HY Mussa, JBO Mitchell, AM Afzal
Pattern recognition letters 63, 30-35, 2015
182015
Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and postmarketing reports
IA Smit, AM Afzal, CHG Allen, F Svensson, T Hanser, A Bender
Chemical Research in Toxicology 34 (2), 365-384, 2020
172020
Bridging of anions by hydrogen bonds in nest motifs and its significance for Schellman loops and other larger motifs within proteins
AM Afzal, F Al‐Shubailly, DP Leader, EJ Milner‐White
Proteins: Structure, Function, and Bioinformatics 82 (11), 3023-3031, 2014
142014
Probabilistic Random Forest improves bioactivity predictions close to the classification threshold by taking into account experimental uncertainty
LH Mervin, MA Trapotsi, AM Afzal, IP Barrett, A Bender, O Engkvist
Journal of Cheminformatics 13, 1-17, 2021
122021
Prediction of UGT-mediated metabolism using the manually curated MetaQSAR database
A Mazzolari, AM Afzal, A Pedretti, B Testa, G Vistoli, A Bender
ACS medicinal chemistry letters 10 (4), 633-638, 2019
122019
New associations between drug-induced adverse events in animal models and humans reveal novel candidate safety targets
KA Giblin, D Basili, AM Afzal, L Rosenbrier-Ribeiro, N Greene, I Barrett, ...
Chemical Research in Toxicology 34 (2), 438-451, 2020
102020
Information-derived mechanistic hypotheses for structural cardiotoxicity
F Svensson, A Zoufir, S Mahmoud, AM Afzal, I Smit, KA Giblin, ...
Chemical Research in Toxicology 31 (11), 1119-1127, 2018
92018
Extending in Silico Protein Target Prediction Models to Include Functional Effects
LH Mervin, AM Afzal, L Brive, O Engkvist, A Bender
Frontiers in Pharmacology 9, 613, 2018
92018
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes
E Semenova, ML Guerriero, B Zhang, A Hock, P Hopcroft, G Kadamur, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (9), 1212-1224, 2021
52021
Understanding Conditional Associations between ToxCast in Vitro Readouts and the Hepatotoxicity of Compounds Using Rule-Based Methods
SY Mahmoud, F Svensson, A Zoufir, D Módos, AM Afzal, A Bender
Chemical Research in Toxicology 33 (1), 137-153, 2019
52019
Towards understanding antimicrobial activity, cytotoxicity and the mode of action of dichapetalins A and M using in silico and in vitro studies
MA Chama, D Modos, LH Mervin, KBA Owusu, DM Ayine-Tora, B Egyir, ...
Toxicon 193, 28-37, 2021
32021
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Articles 1–20