| Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice Y Tong, H Yamaguchi, E Giaime, S Boyle, R Kopan, RJ Kelleher III, ... Proceedings of the National Academy of Sciences 107 (21), 9879-9884, 2010 | 557 | 2010 |
| Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway Y Tong, E Giaime, H Yamaguchi, T Ichimura, Y Liu, H Si, H Cai, ... Molecular neurodegeneration 7, 1-16, 2012 | 250 | 2012 |
| Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease CA Da Costa, C Sunyach, E Giaime, A West, O Corti, A Brice, S Safe, ... Nature cell biology 11 (11), 1370-1375, 2009 | 215 | 2009 |
| PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions C Zhang, S Lee, Y Peng, E Bunker, E Giaime, J Shen, Z Zhou, X Liu Current Biology 24 (16), 1854-1865, 2014 | 114 | 2014 |
| Age-dependent dopaminergic neurodegeneration and impairment of the autophagy-lysosomal pathway in LRRK-deficient mice E Giaime, Y Tong, LK Wagner, Y Yuan, G Huang, J Shen Neuron 96 (4), 796-807. e6, 2017 | 111 | 2017 |
| Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening E Giaime, H Yamaguchi, CA Gautier, T Kitada, J Shen PloS one 7 (7), e40501, 2012 | 107 | 2012 |
| Regulation of mitochondrial permeability transition pore by PINK1 CA Gautier, E Giaime, E Caballero, L Núñez, Z Song, D Chan, ... Molecular neurodegeneration 7, 1-15, 2012 | 101 | 2012 |
| ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1 E Duplan, E Giaime, J Viotti, J Sévalle, O Corti, A Brice, H Ariga, L Qi, ... Journal of cell science 126 (9), 2124-2133, 2013 | 90 | 2013 |
| Parkin regulates mitosis and genomic stability through Cdc20/Cdh1 SB Lee, JJ Kim, HJ Nam, B Gao, P Yin, B Qin, SY Yi, H Ham, D Evans, ... Molecular cell 60 (1), 21-34, 2015 | 85 | 2015 |
| Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 E Giaime, C Sunyach, C Druon, S Scarzello, G Robert, S Grosso, ... Cell Death & Differentiation 17 (1), 158-169, 2010 | 79 | 2010 |
| Discovery of NV-5138, the first selective Brain mTORC1 activator S Sengupta, E Giaime, S Narayan, S Hahm, J Howell, D o’Neill, ... Scientific reports 9 (1), 4107, 2019 | 55 | 2019 |
| Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway E Giaime, C Sunyach, M Herrant, S Grosso, P Auberger, PJ McLean, ... Journal of biological chemistry 281 (17), 11515-11522, 2006 | 39 | 2006 |
| p53‐Dependent control of cell death by nicastrin: lack of requirement for presenilin‐dependent γ‐secretase complex R Pardossi‐Piquard, J Dunys, E Giaime, MV Guillot‐Sestier, ... Journal of neurochemistry 109 (1), 225-237, 2009 | 28 | 2009 |
| p53-dependent control of transactivation of the Pen2 promoter by presenilins J Dunys, J Sevalle, E Giaime, R Pardossi-Piquard, MP Vitek, P Renbaum, ... Journal of cell science 122 (21), 4003-4008, 2009 | 22 | 2009 |
| A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics C Zhang, S Lee, Y Peng, E Bunker, C Shen, E Giaime, J Shen, J Shen, ... Cell Research 25 (3), 394-397, 2015 | 12 | 2015 |
| Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2 J Dunys, T Kawarai, E Giaime, S Wilk, M Herrant, P Auberger, ... Neurodegenerative Diseases 4 (2-3), 156-163, 2007 | 8 | 2007 |
| Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease AS Soehn, T Franck, S Biskup, E Giaime, C Melle, R Rott, D Cebo, ... neurogenetics 11, 203-215, 2010 | 5 | 2010 |
| Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy S St-Cyr, DD Child, E Giaime, AR Smith, CJ Pascua, S Hahm, E Saiah, ... Plos one 17 (8), e0273710, 2022 | 3 | 2022 |
| Regulation of mitochondrial function by PINK1, Parkin and DJ-1 E Giaime, J Shen Molecular Neurodegeneration 8 (Suppl 1), O13, 2013 | 1 | 2013 |
| Regulation of mitochondrial permeability transition pore by PINK1 E Caballero, L Núñez, Z Song, C Villalobos, E Giaime, D Chan, J Shen BioMed Central, 2012 | | 2012 |
