P. Lynne Howell
P. Lynne Howell
The Hospital for Sick Children
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Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl
MJ Franklin, DE Nivens, JT Weadge, PL Howell
Frontiers in microbiology 2, 167, 2011
The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix
KM Colvin, Y Irie, CS Tart, R Urbano, JC Whitney, C Ryder, PL Howell, ...
Environmental microbiology 14 (8), 1913-1928, 2012
Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix
LK Jennings, KM Storek, HE Ledvina, C Coulon, LS Marmont, ...
Proceedings of the National Academy of Sciences 112 (36), 11353-11358, 2015
Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange
LR Hmelo, BR Borlee, H Almblad, ME Love, TE Randall, BS Tseng, C Lin, ...
Nature protocols 10 (11), 1820-1841, 2015
The phage λ major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system
LG Pell, V Kanelis, LW Donaldson, P Lynne Howell, AR Davidson
Proceedings of the National Academy of Sciences 106 (11), 4160-4165, 2009
Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria
JC Whitney, PL Howell
Trends in microbiology 21 (2), 63-72, 2013
Structure and function of S-adenosylhomocysteine hydrolase
MA Turner, X Yang, D Yin, K Kuczera, RT Borchardt, PL Howell
Cell biochemistry and biophysics 33, 101-125, 2000
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms
P Baker, PJ Hill, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee, ...
Science advances 2 (5), e1501632, 2016
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength
MA Turner, CS Yuan, RT Borchardt, MS Hershfield, GD Smith, PL Howell
Nature structural biology 5 (5), 369-376, 1998
The 2.1. ANG. resolution structure of iron superoxide dismutase from Pseudomonas ovalis
BL Stoddard, PL Howell, D Ringe, GA Petsko
Biochemistry 29 (38), 8885-8893, 1990
Femtomolar transition state analogue inhibitors of 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli
V Singh, GB Evans, DH Lenz, JM Mason, K Clinch, S Mee, GF Painter, ...
Journal of Biological Chemistry 280 (18), 18265-18273, 2005
Structural basis for catalysis and inhibition ofn-glycan processing class I α1, 2-mannosidases
F Vallée, K Karaveg, A Herscovics, KW Moremen, PL Howell
Journal of Biological Chemistry 275 (52), 41287-41298, 2000
Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-. ANG. resolution: Identification of the active site and possible …
DJ Neidhart, PL Howell, GA Petsko, VM Powers, R Li, GL Kenyon, ...
Biochemistry 30 (38), 9264-9273, 1991
Architecture of the type II secretion and type IV pilus machineries
M Ayers, PL Howell, LL Burrows
Future microbiology 5 (8), 1203-1218, 2010
PilM/N/O/P proteins form an inner membrane complex that affects the stability of the Pseudomonas aeruginosa type IV pilus secretin
M Ayers, LM Sampaleanu, S Tammam, J Koo, H Harvey, PL Howell, ...
Journal of molecular biology 394 (1), 128-142, 2009
Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa
JC Whitney, KM Colvin, LS Marmont, H Robinson, MR Parsek, PL Howell
Journal of Biological Chemistry 287 (28), 23582-23593, 2012
AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin
CL Keiski, M Harwich, S Jain, AM Neculai, P Yip, H Robinson, JC Whitney, ...
Structure 18 (2), 265-273, 2010
Identification of heavy-atom derivatives by normal probability methods
PL Howell, GD Smith
Journal of applied crystallography 25 (1), 81-86, 1992
Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding
A Zarrine-Afsar, S Wallin, AM Neculai, P Neudecker, PL Howell, ...
Proceedings of the National Academy of Sciences 105 (29), 9999-10004, 2008
Functional role of conserved residues in the characteristic secretion NTPase motifs of the Pseudomonas aeruginosa type IV pilus motor proteins PilB, PilT and PilU
P Chiang, LM Sampaleanu, M Ayers, M Pahuta, PL Howell, LL Burrows
Microbiology 154 (1), 114-126, 2008
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